Indications -- scarring, fibrosis, adhesions, keloids Message Board

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Biotech / Medical : Indications -- scarring, fibrosis, adhesions, keloids

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From: scaram(o)uche	8/31/2006 12:04:56 AM
	of 32

Liver Transpl. 2006 Aug 24;12(9):1431-1434 [Epub ahead of print] The amazing regenerative powers of the liver.Perkins JD. Liver Transplantation Worldwide, University of Washington Medical Center, Seattle, WA. The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration. (Science 2006;312:104-107.).

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