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Biotech / Medical : Infinity Pharmaceuticals
INFI 0.0160-4.8%Sep 29 5:00 PM EST
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To: Mike McFarland who wrote (78)8/31/2006 11:05:46 PM
From: Mike McFarland   of 210
 
(had to look a couple things up)

Pharmacophore - A pharmacophore is the
ensemble of steric and electronic features that is necessary
to ensure the optimal supramolecular interactions with a
specific biological target structure and to trigger (or to
block) its biological response. A pharmacophore does not
represent a real molecule or a real association of
functional groups, but a purely abstract concept that
accounts for the common molecular interaction capacities of
a group of compounds towards their target structure.

Privileged structure - Substructural
feature which confers desirable (often drug- like)
properties on compounds containing that feature. Often
consists of a semi- rigid scaffold which is able to present
multiple hydrophobic residues without undergoing hydrophobic
collapse.

bioscreening.net
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