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Gold/Mining/Energy : Vasogen-- VAS on TSE
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To: Pluvia who wrote (365)9/7/2006 8:48:19 AM
From: Clarksterh  Read Replies (2) of 377
 
1. likely not data mining - BECAUSE
2. they were pre-determined subgroups AND
3. p values, number of events and number of patients in the subgroup point to real results

While I agree that there probably is something there (p=0.24 means only a 12% chance that the final result was due to randomness), it is very clear that this latest release is data mining. Why?

If you look at the remaining population (2400 minus 1300)you'll find that their p value is quite low IN THE WRONG DIRECTION. Unless there is a CRYSTAL clear explanation for this, this makes the touted benefitted subgroup extremely doubtful. Were I them and determined to run another trial I would take the above and Bonferroni very seriously. At most I would run the trial in the subgroup they first announced - NYHA class II.

Clark
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