Vasogen-- VAS on TSE Message Board

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Gold/Mining/Energy : Vasogen-- VAS on TSE

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To: Stephen O who wrote (369)	9/7/2006 7:45:24 PM
From: Clarksterh	of 377

They only split into classes II, III and IV basically. They didn't. A quote from their recent PR: "In addition, an exploratory analysis based on pre-specified subgroups, which comprised 72% of the patient population and excluded only those patients in NYHA Class III/IV with a prior history of heart attack and an ejection fraction equal to or below the median (EF=23%), showed that Celacade reduced the risk of death or first cardiovascular hospitalization by 21% (n=1,746 patients, 560 events, p=0.005)." They split it into at least the following three classes: a) NYHA class II, III or IV b) Previous heart attack or not c) Ejection fraction above median or below median. That by itself with all possible standalones (7) or 2x2 intersections (there are 16 possible) and all possible unions of 2 of the above (some form of combinitorial) is over 100 possibilities. And this doesn't even cover the other possible categories that they probably looked at that weren't good enough (e.g. baseline CRP above median or below). All in all I'd be stunned if they hadn't, effectively(!), looked at 100's of combos. Again, the telling stat is that the remainder will actually be patients that are very stat sig for being HURT by Celacade. Whenever you see that you should STRONGLY(!!!) suspect way way way too much datamining. Clark

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