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Gold/Mining/Energy : Vasogen-- VAS on TSE
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To: Clarksterh who wrote (366)9/11/2006 10:42:51 AM
From: Pluvia  Read Replies (1) of 377
 
I suggest you read the data more carefully.

~ Remove prior heart attack from class II/III/IV patients and your p value is .0003 [subgroup of 1305 of 2400 patients]

~ Remove prior heart attack from class III/IV and all class II patients; your p value is .005 [subgroup of 1747 of 2400 patients]

Obviously damaged heart tissue seems to be key. Given VSGN's admission [buried in a publication, not via pr] they had done no dose ranging, these are pretty impressive results with a shot in the dark dose.

We look at these data for several reasons; two others are in this space - what implications does this have for apoptotic therapies in general; and, who has the best apoptotic therapy.

We're pretty sure we know the answer, and with several multiple billion dollar markets being identified, we think there's some substantial value to be found before the crowd clues in.

>>>If you look at the remaining population (2400 minus 1300)you'll find that their p value is quite low IN THE WRONG DIRECTION. Unless there is a CRYSTAL clear explanation for this, this makes the touted benefitted subgroup extremely doubtful. Were I them and determined to run another trial I would take the above and Bonferroni very seriously. At most I would run the trial in the subgroup they first announced - NYHA class II.
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