Vasogen-- VAS on TSE Message Board

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Gold/Mining/Energy : Vasogen-- VAS on TSE

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To: Clarksterh who wrote (372)	9/11/2006 1:10:49 PM
From: Pluvia	Read Replies (1) of 377

>>I understand the implicit putative MOA for their stat sig subgroup. But you need to explain why the damaged heart group was actively hurt by the treatment - my approx estimate of the p value for that group is better than p=0.05 that the excluded patients were HURT by treatment not only are you off mark with that shot, but you're so far off you may have hit yourself in the buttocks. my suggestion: fire your calculator or stop feeding it crack. hint: what did the control population of the same excluded pts do? >>>a) do heart attack class IIs really have that much in common with non-heart attack class III/IV's? after initial heart attack hospitalization rates skyrocket; check the stats in other studies. >>>b) I think you would make the same argument if the subgroup analysis said "Patients with QcT interval better than X" or "heart size less than Y" or ... . I could invent 100 categories of healthier patients and I GUARANTEE that I could find a permuted 'subgroup' combination that comprised greater thant 50% of 2400 patients that was significantly stat sig. ok now you're just being juvenile. you cannot compare pre-defined subgroups with mumbo jumbo. >>>>c) Whatever group was added to the 1305 subgroup to make it into 1747 subgroup was clearly nowhere near stat sig since the p value went up by more than a factor of 10 with the addition of only 442 patients. They are stretching to make the group look as large as possible. agree; that's obvious. Suggestion: go the vasogen website, download the presentation slides. read stats on implications of first hear attack on hospitalization rates; put your calculator on crack free diet. consider control and treated groups.

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