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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation
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To: nigel bates who wrote (553)9/22/2006 1:13:35 PM
From: keokalani'nui   of 631
 
Orphan nuclear receptor directs differentiation of proinflammatory cells

Last Updated: 2006-09-21 15:11:49 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Interleukin (IL)-17-producing T lymphocytes and proinflammatory cells are thought to play a key role in autoimmune diseases. Now US researchers have identified an orphan nuclear receptor that drives their formation.

Understanding how these T cells are formed could lead to novel antiinflammatory therapies, according to the report in the September 22nd issue of Cell.

Using various laboratory techniques, Dr. Daniel J. Cua, from Schering-Plough BioPharma in Palo Alto, California, and colleagues show that the orphan nuclear receptor ROR-gamma-t induces the transcription of IL-17-encoding genes in naïve CD4+ T helper cells.

The researchers also found that the T cells need ROR-gamma-t to produce IL-17 in response to IL-6 and transforming growth factor-beta.

Histologic analysis in mice showed that IL-17-producing T cells are constitutively expressed throughout the lamina propria in the intestine. These cells, however, were not present in mice lacking ROR-gamma-t or IL-6. Lastly, the absence of these cells was associated with a reduction in autoimmune disease.

ROR-gamma-t is "likely to be an excellent target for pharmacologic intervention in inflammatory diseases that result in autoimmunity and cancer progression," the researchers conclude.

Cell 2006;126:1121-1133.
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