Grapes work too, as resveratrol is in the skin of the grape.
Da skinna uv dah Grappa-->
Later studies showed that resveratrol prolongs the lifespan of the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster.[citation needed] In 2006, it also extended the maximum lifespan of a short-lived fish, Nothobranchius furzeri, by 59%, and extended its median lifespan by 56%. Also noted were an increase in swimming performance, an increase in cognitive performance (learning tasks), and a lack of neurofibrillary degeneration (found in a control group). The authors observed that "[resveratrol's] supplementation with food extends vertebrate lifespan and delays motor and cognitive age-related decline could be of high relevance for the prevention of aging-related diseases in the human population."[7] Later in 2006, a report in the journal Nature by Sinclair's laboratory showed that the compound improves health and survival of mice on a high-calorie diet[8].
The mechanisms of resveratrol's apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. This seems to function by means of lipase inhibition, reducing the absorption of fat through intestinal walls.
Only the "Trans" form of the molecule is capable of activating the mammalian SIRT1 gene in vitro; this is also the form predominantly found in red grape skins and red wine. Red grapes grown in some regions (such as New York state) often have much higher concentrations of resveratrol based on the cooler climate and the resulting increase in fungal attacks that promote resveratrol production.
Alcohol, in discreet moderation also reduces cholesterol markedly. It may in large quantities increase the risk of stroke. So moderation MUST be applied. Women should not do much of that. Their tolerance before becoming imperiled by alcohol is much lower. As few as 5 glasses of wine are a statistical hazard for women whereas men can tolerate as much 2 small glasses a day.
In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. Other researchers indicate that resveratrol retains its health effects rather well. Most commonly-available supplements tested have no ability to stimulate the Sirtuin 1 enzymes.[citation needed]
Resveratrol seems to be removed from the body very quickly, perhaps in less than 30 minutes. Quercitin and lecithin seem to prolong the presence of resveratrol in the body, and are frequently included in many resveratrol supplements. It is possible that sipping red wine several times daily enhances its health effects, but moderation is advised due to the alcohol content [citation needed]. Similarly, use of resveratrol supplements in small quantities several times daily may increase its effect over taking a large dose once daily. [citation needed]
Resveratrol interferes with all three stages of carcinogenesis - initiation, promotion and progression. Experiments in various cell types and isolated subcellular systems in vitro imply many mechanisms in the pharmacological activity of resveratrol. These mechanisms include inhibition of the transcription factor NF-kB, cytochrome P450 isoenzyme CYP1A1, androgenic actions and expression and activity of cyclooxygenase (COX) enzymes. Resveratrol has been shown to induce Fas/Fas ligand mediated apoptosis, p53 and cyclins A, B1 and cyclin-dependent kinases cdk 1 and 2, and possesses antioxidant and anti-angiogenic properties. Resveratrol is under extensive investigation as a cancer chemopreventive agent.
Resveratrol was reported effective against neuronal cell dysfunction and cell death, and help against diseases such as Huntington's disease [3] and Alzheimer's disease.[4]
Research at the Northeastern Ohio Universities College of Medicine and Ohio State University indicate that resveratrol has direct inhibitory action on cardiac fibroblasts and may inhibit the progression of cardiac fibrosis.[5]
Note that resveratrol bioavailability depends on its conjugate forms: glucuronate and sulfonate, despite that most in-vitro studies use the aglycone form of resveratrol.
[edit] Physiological effects
It is alleged by test authority that resveratrol is best absorbed (preserved) in an enterically coated pill. Resvertrol aids the plant as it is an antifungal.
Links were provided in a previous post about ten posts back or less.
en.wikipedia.org
The amount of resveratrol in food substances varies greatly. Ordinary non-muscadine Red wine contains between 0.2 and 5.8 mg/L [1], depending on the grape variety, whilst white wine has much less - the reason being that red wine is fermented with the skins, allowing the wine to absorb the resveratrol, whereas white wine is fermented after the skin has been removed. Wines produced from muscadine grapes, however, both red and white, contain more than 40 mg/L.[2],
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