VIVUS SCIENTIFIC INFO,UPDATED 9-29-97:
UPDATES;
1) Dr. David Bell( Urologist ) report on his recent attendance of an ED conference, where Dr Heaton,author of the general article below on " IMPOTENCE "
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2) Dr.Edderd,Urologist, on his recent attendance of another ED conference:
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PREVIOUSLY POSTED, GENERAL OVERVIEW :
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As you go through the scientific evidence collected below, the
following are key points to remember:
SILDENAFIL/Viagra/Pfizer will ONLY work if there is SOME RESIDUAL
HEALTHY penile tissue tha can produce some Nitric Oxide and cGMP.So
Sildenafil ONLY ENHANCES an ERECTION.So it will not work for the
millions that have dead penile nerves and arteries such as the advanced
diabetics;Muse instead works in diseased tissue veven that which does
not produce Nitric Oxide or cGMP.
Thus Sildenefill and Muse are different and treat different stages of
impotence and different patients;and there are millions of them more
than enoough for each ( if SildenAfilf gets approved).
The best way is to use both.
Phentolamine is a non issue as Drs Morrales & Heaton from Queen's
University have commented in the below excellent review article on male impotence.
.
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MEDICAL REVIEW OF IMPOTENCE
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[ collected by TA ]
1 )Sildenafil/Viagra/Pfizer
traders.co.uk
Insulin Dependent Diabetes Trust Database
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2 )Alprostadil/Muse/Vivus
Treatment of men with erectile dysfunction with transurethral
alprostadil Padma Nathan H, Hellstrom WJG, Kuiser FE, Labasky, Tom
Lue,Nolten,Norwood,Peterson, Shabsigh,Tam, V.Place,Gesudheit,and 90
other collaborators, for the MUSE study group.
New England Journal of Medicine 1997; 336: 1-7
(125-1000mgm) administered intra-urethrally in the office. Of these
996 men ( 65.9 % )had a erectile response satisfactory for intercourse
and were subsequently entered into a placebo controlled double-blind
trial: 461 received Alprostadil and 500 received placebo.Of the 461
receivig Alprostadil 299 had intercourse at least once( 64.9 % ), as
compared to 93 of the 500 who received placebo ( 18.6 %, pCancel
New England Journal of Medicine 1997; 336: 1-7
(125-1000mgm) administered intra-urethrally in the office. Of these
996 men ( 65.9 % )had a erectile response satisfactory for intercourse
and were subsequently entered into a placebo controlled double-blind
trial: 461 received Alprostadil and 500 received placebo.Of the 461
receivig Alprostadil 299 had intercourse at least once( 64.9 % ), as
compared to 93 of the 500 who received placebo ( 18.6 %, p<0.001 ) ). On average 7 of 10 men who received Alprostadil were followed by
intercourse in men resposive to treatment.
The efficacy of Alprostadil was similar regardless of aga or the cause
of erectile dysfunction, including vascular disease, diabetes, surgery
and trauma ( p<0.001 for all comparisons with placebo ) .
10.8% of patients suffered from penile pain but this rarely resulted in discontinuing treatment. Hypotension occurred in the clinic in 3.3 % of men receiving Alprostadil.Hypotension- related symptoms were uncommon at home.No men had priapism or penile fibrosis.
( from the Departments of Urology of:
Univ of Southern California;The Mayo Clinic ; Tulane Univ Med Center;St
Louis Univ;Univ of Utah;Univ of Calif;Univ of Wiconsin;Univ of Columbia,
Columbia-Presbyterian Hospital;)
This is an important paper with large numbers of patients in a well
organised study.
The response rates appear surprisingly good in patients with vasculogenic impotence according to this study.
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3 )Alprostadil/Muse/Vivus after radical prostatectomy
pslgroup.com
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4 )Alprostadil/Muse/ Vivus in Diabetics, one of the largest causes of
impotence:
vivus.com
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5 ) General Review of Impotence, by Drs Morrales and Heaton,
Dept of Urology,Queen's Univ. Kingston Ont. Can.
urol-int.org
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6 )Sample of an Impotence Clinic literature.
peles.com
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7 )Post by Dr BWLandes on Phentolamine/Vasomax/Zonagen, on it's EXTREMELY
DANGEROUS SIDE EFFECTS; NOT SAFE FOr HUMAN ORAL CONSUMPTION !! plus
assorted references on ERECTILE DYSFUNCTION; Everything you always
wanted to know but where afraid to ask:
www3.techstocks.com
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