>>Are you asking if 103 might also lock the receptor into its inactive form, and thus contribute to cardio side-effects? I believe that the answer is "yes", but we don't know anything more from this abstract than before?? I guess that I don't understand what you're asking.... we knew that 103 was an inverse agonist, and we knew that 2A is expressed on cv tissue.<<
Yes, that's what I was asking. didn't realize the cv side effects were an issue with "highly selective" 5-HT2a inverse agonists, too. Common knowledge if you're paying attention? If so, sorry for wasting your time, but I appreciate the answer.
>> aren't we baseline concerned about cardio side effects, and don't we just need to design molecules and do the preclinical and clinical testing?<<
Yup. Do you think ACP-103 has been designed without a certain moiety (or something like that) that would cause cv effects, so that the reason we are not seeing them is not because the trials are small, but because they won't come up? That would be nice. To my knowledge, we haven't seen what the side effects were in murine models. Maybe one would if one paid for this article:
Message 22165113
and maybe one wouldn't.
How come so much animal data seems to be a secret? Because we investors might misinterpret it, or for competitive reasons? I remember one biofreak's (you probably remember who it is) comments years ago after watching a video presentation involving LEXG Alzheimer's mice that had been given a LEXG compound for Alzheimer's and were doing the swim test or a maze. One seemed to be swimming/turning in circles. I think it put him off the whole company, which as things are turning out, was the correct attitude.
Hey, you can only take your Volvo so far down those forest roads. Get the Tacoma or whatever. Why should we stop you? It's not like you can't afford one; you probably daytrade your way to a new Tacoma every week. Concerned about the gas guzzling aspect? Aren't there some hybrids coming out? You might have to daytrade for two weeks for one of those . . .
Cheers, Tuck |
