SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Welcome to the POTP board, the DPP-IV company
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: rareearth42 who wrote (56)11/20/2006 9:16:17 AM
From: drbio45  Read Replies (1) of 90
 
I beg to differ regarding your interpretation of MCU's trial on a couple of points. first of all, most vitamins on the market contain pyridoxal-5-phosphate, precisely the chemical composition of MCU's "MC-1". Take a look at this article for a clear description:

theheart.org

Other vitamins may have a mixture of pyridoxine, pyridoxamine, and pyridoxal phosphate, but pyridoxal-5-phosphate is the active form of the vitamin.

Next, the MEND-CABG trial did indeed show a significant benefit of the 250 mg dose of vitamin B6, but the 750 mg dose wasn't significant. This is a big red flag, as I would expect a real effect to have a dose response. Remember we were all excited about ALXN's significant results in their comparable big phase 2 studies with pexelizumab.

You seem to be blinded by the fact that it is an analog of b-6.

Taking b-6 does not help the people having cabg surgery so it is not a threat. The good thing about it being an analog of b-6 is that it is safe.

It doesn't bother me that the 750mg wasn't better than the 250mg,they had an explanation on the conference call. That isn't to say that 400 or 500 wouldn't be better than 250 but they didn't test that dose

Cardiome's 600 dose was no better than the 300. They will be trying 450 and less than 300 in the next trial.

the trend in the 750 was good enough to confirm efficacy of the 250, I didn't need the 750 to me statistical significance.
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News