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Biotech / Medical : Millennium Pharmaceuticals, Inc. (MLNM)
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To: tuck who wrote (2758)12/3/2006 12:14:28 AM
From: tnsaf  Read Replies (1) of 3044
 
The results for combining RAD001 with Rituximab are not included in the table but are shown in a bar graph. It was highly synergestic with all dosage levels of RAD001
Jason

Table 1 CI values generated by isobologram analyses for combination drug studies of varying doses of RAD001 (2–2000 nM) with either
(a) doxorubicin, (b) vincristine, (c) paclitaxel, (d) vorinostat or (e) bortezomib with either Jeko1, SP49 or NCEB1 cells
 
RAD001			2 nM 		20 nM 		200 nM 		2000 nM 
(a) Doxorubicin (nM) 
Jekol (25) 		1.2 (Ant) 	0.21 (Syn) 	0.33 (Syn) 	0.8 (Syn) 
NCEB1 (100) 	        0.58 (Syn) 	0.46 (Syn) 	0.38 (Syn) 	0.43 (Syn) 
SP49 (5) 		0.38 (Syn) 	0.18 (Syn) 	0.18 (Syn) 	0.40 (Syn) 
(b) Vincristine (nM) 
Jekol (0.25) 		0.17 (Syn) 	0.09 (Syn) 	0.08 (Syn) 	0.07 (Syn) 
NCEB1	(1) 		0.74 (Syn) 	0.49 (Syn) 	0.44 (Syn) 	0.28 (Syn) 
(c) Paclitaxel (nM) 
Jekol (2.5) 		1.27 (Ant) 	0.49 (Syn) 	0.52 (Syn) 	0.94 (Add) 
NCEB1 (5) 		0.50 (Syn) 	0.49 (Syn) 	0.43 (Syn) 	0.42 (Syn) 
SP49 (5) 		0.72 (Syn) 	0.67 (Syn) 	0.65 (Syn) 	0.60 (Syn) 
(d) Vorinostat (nM) 
Jekol (500) 		0.04 (Syn) 	0.01 (Syn) 	0.02 (Syn) 	0.07 (Syn) 
SP49 (1000) 		0.20 (Syn) 	0.17 (Syn) 	0.18 (Syn) 	0.18 (Syn) 
(e) Bortezomib (nM) 
Jekol (7.5) 		0.48 (Syn) 	0.33 (Syn) 	0.40 (Syn) 	0.78 (Syn) 
NCEB1 (10) 		0.72 (Syn) 	0.46 (Syn) 	0.43 (Syn) 	0.40 (Syn) 
SP49 (5) 		0 56 (Syn) 	0.24 (Syn) 	0.54 (Syn) 	2.7 (Ant)

Abbreviations: Add, additive; Ant, antagonistic interactions; CI, combination index; Syn, synergistic.
CI values <0.9 indicate synergism, CI<0.3 depicts strong synergism and CI >0.7 represents moderate synergism. CI values between 0.9 and 1.1
indicate additive interactions, whereas CI values >1.1 denote antagonism
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