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Biotech / Medical : Metabasis Therapeutics (MBRX)
MBRX 0.467+3.3%Oct 31 9:30 AM EDT

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From: LJM12/13/2006 5:59:08 PM
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Valeant Pharmaceuticals And Metabasis Therapeutics License Rights To Hepatitis B Compound Pradefovir To Schering-Plough Corp>MBRX

Dec 13, 2006 17:01:00 (ET)

DOW JONES NEWSWIRES

Valeant Pharmaceuticals International (VRX) and Metabasis Therapeutics Inc. (MBRX) agreed to assign and license development and commercial rights to pradefovir to Schering-Plough Corp. (SGP), the companies said after Wednesday's closing bell.

Under the agreement, Schering-Plough will make an upfront payment of $19.2 million to Valeant and $1.8 million to Metabasis, and will pay up to $90 million in additional fees to both companies upon the achievement of certain development and regulatory goals, Valeant said.

Valeant would receive about $65 million of the additional fees, while Metabasis would get $25 million.

Schering-Plough will also pay royalties to Valeant and Metabasis if pradefovir is commercialized and will be responsible for all forward research and development activities, Schering-Plough said.

Valeant licensed pradefovir from Metabasis in 2000 and has been conducting clinical trials for its use to treat compensated chronic hepatitis B. Pradefovir is a compound that uses Metabasis' technology to enable higher concentrations of the drug in the liver, the primary site of replication for the hepatitis B virus.

The deal is expected to close in the first quarter.

-Ana Campoy; 415-439-6400; AskNewswires@dowjones.com

(END) Dow Jones Newswires

December 13, 2006 16:58 ET (21:58 GMT)
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