TELK -- Telik, Inc. Message Board

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Biotech / Medical : TELK -- Telik, Inc.

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To: idos who wrote (784)	12/26/2006 9:51:50 AM
From: tuck	Read Replies (1) of 887

Yup, closed my hedged position just now for a minor loss. My Mom owns a bit, but she doesn't do options. Hurts her a bit worse. Interesting way to whiff in ASSIST-3. >>The ASSIST-3 trial, a 244 patient randomized trial conducted in the U.S., was designed to demonstrate a statistically significant improvement in overall tumor response to the combination of TELCYTA plus carboplatin compared to liposomal doxorubicin in the second-line treatment of platinum resistant ovarian cancer. Under the trial protocol, patients were to have received treatment until tumor progression or unacceptable toxicity. However, a major discordance was observed between the clinical review of the tumor scans and the independent radiology review. Approximately 25% of the patients were discontinued prematurely from the assigned study treatment as judged by the independent review of the scans. Therefore, the company believes the trial was compromised and may not be suitable for a regulatory submission.<< This would seem to imply that the clinical radiologist(s) was too strict or something. Anyhow, having all those patients discontinue is an irretrievable error, no matter how it happened. Hope all those here with positions were hedged. Cheers, Tuck

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