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Biotech / Medical : Agouron Pharmaceuticals (AGPH)
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To: Joe E. who wrote (1975)10/1/1997 2:26:00 PM
From: margie   of 6136
 
Studies have been presented on "Combination of Viracept and Saquinavir Soft Gel Formulation." Data was supposed to be presented in a session on Tuesday or Wednesday. Where is thestreet.com when you want them? This is pasted from Agouron's release on Monday, 9/29.

Combination of VIRACEPT and Saquinavir Soft Gel Formulation

Preliminary results will be reported from an open study of the combination of VIRACEPT and FORTOVASE(TM) (saquinavir soft gel formulation, SGC) in 14 patients, most of whom had been treated previously with other anti-retroviral drugs. The concomitant administration of standard doses of VIRACEPT increased patients' exposure to saquinavir SGC five-fold. Viral load fell below the limit of quantification (500 copies/mL) in 80% of ten patients who were treated for ten months with the standard dose of VIRACEPT plus 800mg of saquinavir SGC TID. Seven of these patients were also receiving one or more anti-retroviral drugs from the class of reverse transcriptase inhibitors. The HIV mutation uniquely associated with resistance to VIRACEPT was not detected in virus from any of 12 patients studied by genotypic analysis after five to seven months of treatment with the combination. The combination of VIRACEPT and saquinavir SGC was generally well tolerated in the study; the most commonly observed adverse event of moderate or greater intensity was diarrhea.(2)

biz.yahoo.com
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