I am glad to open a discussion on possibly ideas on the mechanics of this valvular disorder and hope others will enter in with ideas.
I base an idea of a "mechanical block" relating to Newsweek depiction of the valvular pathology from the Mayo Clinic findings released early summer....." The case-study patients' heart valves were coated with a white, waxy substance that kept them from closing fully. "........while I have no idea what this coating might be, it does suggest a mechanical contribution to the valvular disease.
I do question your idea of " the drugs may cause some type of electricor electrolytic imbalance in the normal functioning of the valves", as physiologically the valvular action is a passive action.......when pressure builds in the ventricle during systolic contraction such as to overcome aortic pressures, the valve is pushed open and blood flows into the aorta.......when the ventricle relaxes, the aortic pressures against the valve causes it to close.
I am also not aware of the implication that valvular disease would necessarily show up and be directly implicated via EKG........more likely diagnosis would begin with auscultation ( diastolic murmur) followed by echocardiogram, if indicated.
I think the basics are agreed upon.......no one knows what is happening, no causality of valvular disease with fenfluramines has been established, and it will be most unlikely to implicate IPIC for negligence, regardless of what is determined on the issues of causality. Besides, by the time this ever gets into any kind of serious litigation, the patient population with valvular disease relatable to fenfluramines could be nil as resolution will have occurred.........would make for an interesting hypothetical interaction:
Judge: So Mr. Reingold, where are all your clients?
Reingold: Uh gee, your honor, they all got better. |
