VIVUS SCIENTIFIC INFO,UPDATED 10-2-97:
( Final posting today )
NEW AND IMPROVED gg VIVUS SCIENTIFIC INFO,UPDATED 10-2-97:
New? idea of the day: Vivus Frog-stew; or, shorts stewing:
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GENERAL OVERVIEW :
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As you go through the scientific evidence collected below, the
following are key points to remember:
SILDENAFIL/Viagra/Pfizer will ONLY work if there is SOME RESIDUAL
HEALTHY penile tissue tha can produce some Nitric Oxide and cGMP.So
Sildenafil ONLY ENHANCES an ERECTION.So it will not work for the
millions that have dead penile nerves and arteries such as the advanced
diabetics;Muse instead works in diseased tissue veven that which does
not produce Nitric Oxide or cGMP.
Thus Sildenefill and Muse are different and treat different stages of
impotence and different patients;and there are millions of them more
than enoough for each ( if SildenAfilf gets approved).
The best way is to use both.
Phentolamine is a non issue as Drs Morrales & Heaton from Queen's
University have commented in the below excellent review article on male
impotence.
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MEDICAL REVIEW OF IMPOTENCE
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1 )Sildenafil/Viagra/Pfizer
traders.co.uk
Insulin Dependent Diabetes Trust Database
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2 )Alprostadil/Muse/Vivus
Treatment of men with erectile dysfunction with transurethral
alprostadil Padma Nathan H, Hellstrom WJG, Kuiser FE, Labasky, Tom
Lue,Nolten,Norwood,Peterson, Shabsigh,Tam, V.Place,Gesudheit,and 90
other collaborators, for the MUSE study group.
New England Journal of Medicine 1997; 336: 1-7
(125-1000mgm) administered intra-urethrally in the office. Of these
996 men ( 65.9 % )had a erectile response satisfactory for intercourse
and were subsequently entered into a placebo controlled double-blind
trial: 461 received Alprostadil and 500 received placebo.Of the 461
receivig Alprostadil 299 had intercourse at least once( 64.9 % ), as
compared to 93 of the 500 who received placebo ( 18.6 %, pCancel
New England Journal of Medicine 1997; 336: 1-7
(125-1000mgm) administered intra-urethrally in the office. Of these
996 men ( 65.9 % )had a erectile response satisfactory for intercourse
and were subsequently entered into a placebo controlled double-blind
trial: 461 received Alprostadil and 500 received placebo.Of the 461
receivig Alprostadil 299 had intercourse at least once( 64.9 % ), as
compared to 93 of the 500 who received placebo ( 18.6 %, pCancel Changes
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3 )Alprostadil/Muse/Vivus after radical prostatectomy
pslgroup.com
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4 )Alprostadil/Muse/ Vivus in Diabetics, one of the largest causes of
impotence:
vivus.com
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5 ) General Review of Impotence, by Drs Morrales and Heaton,
Dept of Urology,Queen's Univ. Kingston Ont. Can.
urol-int.org
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6 )Sample of an Impotence Clinic literature.
peles.com
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7 ) PHENTOLAMINE/VASOMAX/ZONAGEN:
A dangerous drug. See post 96 on Vivus 1997/1998 thread
by Emergency Room physician, Zebra 365.
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ARTICLES ON ED RELATED TO MUSE :
Excellent Article on use of Alpostadil to hasten ED recovery after
prostatectomy, by needle;
Muse should be forthcoming with similar article in future IMHO; TA
RECOVERY OF SPONTANEOUS ERECTILE FUNCTION AFTER NERVE SPARING RADICAL
RETROPUBIC PROSTATECTOMY WITH AND WITHOUT EARLY INTRACAVERNOUS
INJECTIONS OF ALPROSTADIL.RESULTS OF A PROAPECTIVE, RANDOMISED TRIAL.
By Francesco Montrosi,Giorgio Guazzoni,Luigi Ferrini Stambi,Luigi F. Da
Pozzo,L.Nava,L.Barbieri, Patrizio Rigatti, Giuliano Pizzini and Alberto
Miani.
The Journal of Urology,Vol.158,1408-1410,Oct.1997.postadil after
prostatectomy, by needle;See post:
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Another study on the excellent safety of intravenous ( in the peripheral
vein by drip, and then by local intracavernous injections ) of
Alprostadil in the last, Oct 97 issue of ther Journal of
Urology,Vol158,1403-1497;
PHARMACOKINETICS OF PROSTAGLANDIN E1 AND IT'S MAINMETABOLITES AFTER
INTRACAVERNOUS INJECTION AND SHORT - TERM INFUSION OF PROSTAGLANDIN E1
IN PATIENTS WITH ERECTILE DYSFUNCTION:
BY Willi Cawelo,Horst Schweer, Bruno Dietrich, Hannsjofg WIlhelm,
Seyberth,Albrecht et al:
From the Univ of Marbufg, Ulm, Germany:
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VIVUS THREAD CONTRIBUTORS:
Dr. David Bell( Urologist ) report on his recent attendance of an ED
conference, where Dr Heaton,author of the general article below on "
IMPOTENCE "
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Dr.Edderd,Urologist, on his recent attendance of another ED conference:
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TOPICS OF GENERAL INTEREST:
Exhilarating BOAT RIDE by attorney Mark Stang (gg0:
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