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Biotech / Medical : Millennium Pharmaceuticals, Inc. (MLNM)

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From: Ian@SI	4/4/2007 8:34:25 PM
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Believe they're talking about Revlimid Public release date: 4-Apr-2007 ] Contact: Elizabeth Zimmermann newsbureau@mayo.edu 507-284-5005 Mayo Clinic Multiple myeloma clinical trial closes early ROCHESTER, Minn. -- Mayo Clinic Cancer Center announced today that a multiple myeloma clinical trial has shown a significant improvement in survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone. The study led by the Eastern Cooperative Oncology Group (ECOG) and supported by the National Cancer Institute compared combination treatment of oral medications lenalidomide and either high- or low-dose dexamethasone in 445 patients with newly-diagnosed myeloma. Lenalidomide plus high-dose dexamethasone had a one-year survival rate of 86 percent. The comparative therapy using low-dose dexamethasone showed a significantly higher 96.5 percent overall survival rate at one year, with much less toxicity. "In my opinion, this is the best one-year survival data that I?ve seen in a large phase 3 study in myeloma," says Vincent Rajkumar, M.D., Mayo Clinic hematologist and primary investigator of the ECOG study. "This is a major advance in the treatment of this cancer." All patients on the high-dose dexamethasone arm of the clinical trial will be moved to the low-dose arm. A successor study using lenalidomide plus high-dose dexamethasone was closed early as a result of these findings.

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