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Biotech / Medical : Biotech Valuation

CRSP 56.68

-2.4%

Dec 12 9:30 AM EST

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To: f_mcknuckles who wrote (23685)	5/18/2007 3:13:01 PM
From: Biomaven	Read Replies (2) of 52153

<Cancer in mixed breeds> Very intriguing. I suppose it could be some sort of recessive protective gene that occurs in some pure-bred breeds. Generally we assume mutations specific to a breed are all deleterious, but I don't see any reason why there couldn't be an occasional exception. Dog genetics are very interesting given the wide range of breeds. I assume folks saw the recent discovery of the gene that researchers claim is largely responsible for size differentials between breeds? I've closely followed the issue of a fatal genetic disease (PLE - protein losing enteropathy, a type of inflammatory bowel disease) present in a substantial fraction (perhaps as much as 10%) of US soft-coated wheaten terriers. It's proven very hard to eradicate because it only shows up in middle-aged dogs too late to avoid breeding them. Unfortunately a couple of key US sires had the disease and there is still no test for it. Seems to be dominant with incomplete penetrance, which makes it very hard to determine if a particular dog is at risk. This is a nice survey of current understanding of the dog genome and its relationship to disease: jag.igr.poznan.pl Peter

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