United States Patent Application 20070134814
Kind Code A1
Kajander; E. Olavi ; et al. June 14, 2007
Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease
Abstract
Disclosed are methods and compositions for detecting, analyzing and assessing the significance of calcifying nano-particles. The disclosed methods and compositions generally involve detecting one or more proteins present on a calcifying nano-particle. It has been discovered that particular proteins become associated with calcifying nano-particles. This association provides a means for detecting, classifying, analyzing, categorizing, and assessing calcifying nano-particles. Detecting particular proteins while associated with a calcifying nano-particle can be used to indicate the presence and type of calcifying nano-particle, which can be used to indicate the presence of, or disposition to, diseases or conditions. Multiple proteins on a calcifying particle can be detected. The presence or absence of particular proteins and the pattern of the presence and absence of particular proteins can be used to indicate the presence and type of calcifying nano-particle.
Inventors: Kajander; E. Olavi; (Lakeland, FL) ; Aho; Katja M.; (Siilinjarvi, FI) ; Ciftcioglu; Neva; (League City, TX)
Claims
1. A method for detecting calcifying nano-particles, the method comprising detecting calcifying nano-particles by detecting one or more proteins or components on the calcifying nano-particle.
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