VIVUS SCIENTIFIC AND GENERAL INFO, UPDATED TUESDAY, 10-7-97.
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vivus.com Editorial Board
Editor: TA ( a temporary job;they don't
Pay me. )
CopyEditor:Linda Kaplan
Staff writers:Vivus thread
N E W S ( last 24 hours)
Vivus closed @ 40 9/16 :
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\\ ~ ~ //
( @ @ )
_oOOo___\__^__oOOo____
It's ok, VVUS, we all gotta be 40 someday.
Yes, and even more.
Frostman Oct 3 1997 : #531
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- Check out Vivus intraday chart 10/6/97 ( Brian Malloy,post #514 ).
investor.msn.com./charts/charting.asp?C2=4&Symbol=vvus
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Note: TA will be busy Tues also: no posting during market hours; ( went to look for a real job since this crummy job doesn't pay a penny, gg ).
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[A] | GENERAL OVERVIEW |
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As you go through the scientific evidence collected below, the
following are key points to remember:
SILDENAFIL/Viagra/Pfizer will ONLY work if there is SOME RESIDUAL
HEALTHY penile tissue that can produce some Nitric Oxide and cGMP
( cyclic Guanidine Mono Phospate ).Thus Sildenafil CAN ONLY ENHANCE A P
R E -- E X I S T I N G ERECTION.So THAT it will not work for the
millions that have dead penile nerves and arteries such as the advanced
diabetics, arteriosclerosis;
Muse instead works in diseased tissue even that which does
not produce Nitric Oxide or cGMP.
Thus Sildenefill and Muse are different and treat different stages of
impotence and different patients; Sildenafil the earlier less severe
cases and those that have more of a mental problem with no genital
dysfunction; Muse would be for the next stage perhaps. Men however
present in all different stages and thus both drugs will be need all the
time, either individually or in combination.
The best way will most likely be to use both.
Phentolamine is a non issue as Drs Morrales & Heaton from Queen's
University in Kingston, Ont. Can. have commented in the
excellent review article below ( #5 ) on male impotence in general.
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[B] | MEDICAL ARTICLES REVIEW OF IMPOTENCE |
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1 )Sildenafil/Viagra/Pfizer
traders.co.uk
Insulin Dependent Diabetes Trust Database
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2 )Alprostadil/Muse/Vivus
Treatment of men with erectile dysfunction with transurethral
alprostadil Padma Nathan H, Hellstrom WJG, Kuiser FE, Labasky, Tom
Lue,Nolten,Norwood,Peterson, Shabsigh,Tam, V.Place,Gesudheit,and 90
other collaborators, for the MUSE study group.
( New England Journal of Medicine, Jan. 1997; 336: 1-7 )
Alprostadil was delivered transurethrally in a double -blind
placebo-controlled study of 1511 men, 27 to 88 years of ag, who had
CHRONIC erectile dysfunction.The men were first tested in the clinic
with up to four doses of the drug (125,250,500,and 1000 mcg); those who
had sufficient responseswere randomly assigned to treatment with either
the effective dose of Alprostadil or placebo for three months at home.
RESULTS ; During in- clinic testing, 996 men ( 65.9% ) had erections
sufficient for intercourse.Of these men, 961 reported the results of at
least one home treatment;. Of these996 men ( 65.9 % )had a erectile
response satisfactory for intercourse
and were subsequently entered into a placebo controlled double-blind
trial: 461 received Alprostadil and 500 received placebo.Of the 461
receiving Alprostadil 299 had intercourse at least once( 64.9 % ), as
compared to 93 of the 500 who received placebo ( 18.6 %, p<0.001 ) ). On
average 7 of 10 men who received Alprostadil were followed by
intercourse in men responsive to treatment.
The efficacy of Alprostadil was similar regardless of age or the cause
of erectile dysfunction, including vascular disease, diabetes, surgery
and trauma ( p<0.001 for all comparisons with placebo ) .
10.8% of patients suffered from penile pain but this rarely resulted in
discontinuing treatment. Hypotension occurred in the clinic in 3.3 % of
men receiving Alprostadil.Hypotension- related symptoms were uncommon at
home.No men had priapism or penile fibrosis.
( from the Departments of Urology of:
Univ of Southern California;The Mayo Clinic ; Tulane Univ Med Center;St
Louis Univ;Univ of Utah;Univ of Calif; Peachwood Medical
Group,Clovis,Calif.,Univ of Wiconsin;Univ of Columbia,
Columbia-Presbyterian Hospital;)
( over 100 Urologists participated in the study and are listed in the
Apendix of the article).
This is an important paper with large numbers of patients in a well
organised study.
The response rates appear surprisingly good in patients with
vasculogenic impotence according to this study.
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3 )Alprostadil/Muse/Vivus after radical prostatectomy
pslgroup.com
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4 )Alprostadil/Muse/ Vivus in Diabetics, one of the largest causes of
impotence:
vivus.com
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5 ) General Review of Impotence, by Drs Morrales and Heaton,
Dept of Urology,Queen's Univ. Kingston Ont. Can.
urol-int.org
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6 )Sample of an Impotence Clinic literature.
peles.com
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7 )Post by Zebra 265, internist/Emerg Room physiciqan on
Phentolamine/Vasomax/Zonagen:
on it's EXTREMELY DANGEROUS SIDE EFFECTS; NOT SAFE FOr HUMAN ORAL
CONSUMPTION !!
Plus assorted references on ERECTILE DYSFUNCTION; Everything you always
wanted to know but where afraid to ask:
www3.techstocks.com
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[C] | FURTHER MEDICAL ARTICLES ON ED RELATED TO MUSE |
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a) Excellent Article on use of Alpostadil to hasten ED recovery after
prostatectomy, by needle;
( Muse should be forthcoming with similar article in future IMHO; TA)
RECOVERY OF SPONTANEOUS ERECTILE FUNCTION AFTER NERVE SPARING RADICAL
RETROPUBIC PROSTATECTOMY WITH AND WITHOUT EARLY INTRACAVERNOUS
INJECTIONS OF ALPROSTADIL.RESULTS OF A PROAPECTIVE, RANDOMISED TRIAL.
By Francesco Montrosi,Giorgio Guazzoni,Luigi Ferrini Stambi,Luigi F. Da
Pozzo,L.Nava,L.Barbieri, Patrizio Rigatti, Giuliano Pizzini and Alberto
Miani.
The Journal of Urology,Vol.158,1408-1410,Oct.1997.postadil after
prostatectomy, by needle;See post:
www3.techstocks.com
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b )Another study on the excellent safety of intravenous ( in the
peripheral
vein by drip, and then by local intracavernous injections ) of
Alprostadil in the last, Oct 97 issue of ther Journal of
Urology,Vol158,1403-1497;
PHARMACOKINETICS OF PROSTAGLANDIN E1 AND IT'S MAINMETABOLITES AFTER
INTRACAVERNOUS INJECTION AND SHORT - TERM INFUSION OF PROSTAGLANDIN E1
IN PATIENTS WITH ERECTILE DYSFUNCTION:
BY Willi Cawelo,Horst Schweer, Bruno Dietrich, Hannsjofg WIlhelm,
Seyberth,Albrecht et al:
From the Univ of Marbufg, Ulm, Germany:
www3.techstocks.com
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[D] | VIVUS -THREAD MEDICAL CONTRIBUTORS |
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Dr. David Bell( Urologist ) report on his recent attendance of an ED
conference, where Dr Heaton,author of the general article below on "
IMPOTENCE "
www3.techstocks.com
www3.techstocks.com
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Dr.Edderd,Urologist, on his recent attendance of another ED conference:
www3.techstocks.com
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[E] | TOPICS OF GENERAL INTEREST |
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Exhilarating BOAT RIDE by attorney Mark Stang (gg0:
www4.techstocks.com
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" Where is Wohle ", famous Vivus analyst? He's been unearthed:
www3.techstocks.com
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[F] | INVESTMENT UPDATE ON VIVUS |
===========================
- Options page for VVUS:
From: Navigator One Reply #391
webservices.pcquote.com
-Upcoming Vivus investment conferences
www3.techstocks.com
-Vivus patent by Gene Voss, MD.-
www4.techstocks.com
Review of Vivusm price history since 6-23-97 stock split , by Frostman: www4.techstocks.com
Jeff Vinick, buying Vivus shares, ( DR BOND< post # 551 )
businessweek.com
Vivus short situation as of Fri ., 10-3-97 ( Frostman # 579 )
www4.techstocks.com
Vivus SOES action ?, gg ,Monday ( Kmac 3 586 )
www4.techstocks.com
Vivus "99" eps estimate, by Genesis Merchant, ( Dunkin: Reply #582 ).
www4.techstocks.com
www4.techstocks.com
3 ) Check out Vvius 2nd opinion site;( Dr. Bond, post #207 ):
etrade.stkwtch.com
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| MISCELLANEOUS |
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Richard Singer
<< how to create hyperlinks in SI posts. >>
www3.techstocks.com
Jeff Vinick, buying Vivus shares, ( DR BOND< post # 551 )
businessweek.com |
