IDPH--Positive preliminary results for pivotal trial of ID Message Board

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Biotech / Medical : IDPH--Positive preliminary results for pivotal trial of ID

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To: Maurice Winn who wrote (1759)	7/29/2007 2:20:34 PM
From: Maurice Winn	of 1762

No Mq, it's worse than that. <I guess 5% of people have died who otherwise wouldn't have done if they'd had Rituxan with their original CHOP treatment. So that must a few thousand dead because of the dopey delay in concluding what was completely obvious back in 1998. > Many thousands have died because the Medical Guild couldn't figure out the totally obvious: cancer.gov <Addition of the drug rituximab (Rituxan®, a monoclonal antibody) to a standard chemotherapy regimen for diffuse large-B-cell lymphoma significantly increased survival for patients with good-prognosis disease who were younger than 60. .... Around the three-year mark, 79 percent of the rituximab patients were alive and had yet to see their disease progress, compared to 59 percent of the chemotherapy-only patients. Overall survival at three years was also significantly greater in patients receiving both rituximab and any CHOP-like chemotherapy (93 percent versus 84 percent).> In your attempt to be reasonable and not seem extreme, you underestimated the huge number of deaths resulting from the stupid delay in figuring out that the non-toxic Rituxan would save a LOT of lives. People worry about 911 and terrorism. Swarms more died from neglect = lack of Rituxan. 93 percent vs 84 percent means that of the 16% who died without Rituxan, over half of them would have lived if they had had Rituxan. That is a huge improvement in survival prospects. It is amazing [if it wasn't so normal] that the medical guild is so slow at figuring out the blindingly obvious. It is now nearly 10 years since Rituxan was turned loose. There are surely still people being poisoned with CHOP without the benefit of Rituxan and better yet, Zevalin. I haven't been following the matter in recent years as I don't have a personal need. Mqurice

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