Merrill:
  Raising estimates on strong execution
  OSIP raised full-year GAAP EPS guidance to $1.40 from $1.00, signaling disciplined expense control and growing diabetes royalties and Ex-US Tarceva revenues. Also, the dedicated Tarceva salesforce became active only in late May, and should have a stronger effect on Tarceva revenues going forward. In addition, we expect Macugen divestiture by YE07 to complete the sales of the eye business. Finally, we are raising estimates based on firm expense control and growth driven by diabetes royalties and Ex-US Tarceva revenues. Reiterate BUY.
  Dedicated salesforce should boost 2H Tarceva revs The dedicated Tarceva salesforce was active only one month in 2Q, thus we expect a stronger effect on revenues going forward. DNA sales reps had previously split time between Herceptin and Tarceva, but now DNA reps will focus only on Tarceva. The net effect on the JV profit split is estimated at +$3 mn for FY2007, and could push JV profitability towards 40% for OSIP.
  Expect full Macugen divestiture by YE07 We expect Macugen divestiture by year-end '07 to complete the sale of the eye business. Although the company is selling its PDGF aptamer program and Macugen separately, we believe OSIP will find a buyer by year-end. OSIP will retain ~$140 mn in Macugen non-operating losses (NOLs), but we look for the company to efficiently divest the eye business and re-focus efforts on diabetes and oncology development.
  Raising estimates on expense control, revenue growth We are raising our estimates based on higher EPS guidance, a better Tarceva JV conversion factor, higher license and milestone revenues, and lower R&D and SG&A expenses. Our non-GAAP EPS (ex-options) estimate rises to $1.79 from $1.49 in '07, to $1.80 from $1.72 in '08, to $1.63 from 1.58 in '09, and to $2.06 from $2.01 in '10. |