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Biotech / Medical : ACADIA Pharmaceuticals Inc (ACAD)
ACAD 25.03+0.8%Nov 28 12:59 PM EST

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To: tuck who wrote (440)10/3/2007 3:22:06 PM
From: mopgcw   of 588
 
Citi: ACADIA Pharmaceuticals Inc (ACAD) Initiation of
Initiating with a Hold (2S) Rating and $19 Price Target coverage Y

* Potential partnership only catalyst over next 12-months -
Despite having mulitple shots on goal with two clinical
drug candidates, there will not be any data released over
the next year and the only potential catalyst will be a
partnership for Pimavanserin. While we believe Pimavanserin
Phase II data for co-therapy in schizophrenia will enable
Acadia to find a partner, expectations for a partnership
are largely priced into the stock. Therefore, there may be
limited upside to the stock at current levels over the next
twelve months unless a partnership with a major
pharmaceutical company is announced.
* Pimavanserin Phase II schizophrenia data with Risperdal
promising, but unclear if it will translate to other
atypical antipsychotic drugs - Pimavanserin may provide
comparable efficacy but fewer side effects by enabling
patients to use lower doses of current atypical
antipsychotics when combined with Pimavanserin. Based on
independent studies, we believe additional Phase II work
may need to be conducted before a pivotal Phase III program
can begin.
* Pimavanserin targets underserved Parkinson's Disease
Psychosis (PDP) Market - Theoretically, Pimavanserin should
demonstrate a benefit in PDP but other antipsychotics have
had difficulty obtaining clinical success in trials.
* ACP-104 for monotherapy in schizophrenia is an exciting
program and Phase IIb results expected 2H08 will help
delineate its efficacy and safety profile
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