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Biotech / Medical : HuMAB companies
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From: Germanecki10/4/2007 9:42:24 AM
   of 1022
 
Johnson&Johnson Daughter Centocor was the third mAb in clinic with Morphosys.
Named CNTO 888
target CC-Chemokine Ligand 2 (CCL2)

clinicaltrials.gov

First Study of the Safety of CNTO 888 in Patients With Solid Tumors

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CNTO 888 is a monoclonal antibody. Antibodies are substances in the body that are involved in many biological processes. CNTO 888 is thought to work by blocking a protein called CC-Chemokine Ligand 2 (CCL2). In research studies CCL2 has been shown to increase the growth of new blood vessels which help the tumor to survive. When new blood vessels do not grow, tumors cannot get the food or oxygen they need to grow. Blocking CCL2 may help fight disease.
..........

ncbi.nlm.nih.gov

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CNTO 888, a human mAb specific for human MCP-1, was obtained by antibody phage display in collaboration with MorphoSys AG. The isolated DNA sequence of the antibody was biased towards bacterial codons, reflecting the engineering of the Fab library for phage display expression in Escherichia coli.
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