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Biotech / Medical : AMLN (DIABETES DRUGS)

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To: David Bogdanoff who wrote (843)	10/11/1997 4:27:00 AM
From: Henry Niman	of 2173

David, Here's some info (from a diabetes discussion group) on glycosylated Hemoglobin (Hb1Ac) which should be interest to LGND, ERGO, and AMLN shareholders. As I said earlier, Rezulin produced an average drop of 3% (from 11% to 8%). AMLN and ERGO shareholders are excited about drops between 0.5% and 1.0%. As can be seen in the table below, a 3% drop (from 11% to 8%) can have a major clinical impact. A 0.5% to 1.0% drop is pretty iffy: GLYCOSYLATED HEMOGLOBIN Red blood cells flow constantly through your bloodstream. Hemoglobin is the part of the cell that carries oxygen. When hemoglobin comes in contact with glucose in the bloodstream, the glucose attaches itself to it (glycosylation). The more glucose there is in the bloodstream, the more glucose builds up in the cell. People sometimes call the glycosylated hemoglobin (or glycohemoglobin) test an HbA1c test. Hb refers to hemoglobin, and A1c refers to the change that takes place in the hemoglobin when the glucose attaches to it. The HbA1c test results refers to the amount of glucose that is attached to the hemoglobin. The result (in percentage) shows the average amount of glucose that has been in your blood over the last 120 days. Here's how you can figure out what your blood glucose level was during the 3 months before your test: HbA1c Value Average daily blood glucose level ----------- --------------------------------- 6% 120 mg/dL (pretty good) 8% 180 mg/dL (not too bad) 10% 240 mg/dL (not good) 13% 330 mg/dL (dangerous) KNOW YOUR NUMBER! Are you 7.1%? You're doing pretty well, keep up the good work. Are you 8.9%? Watch out, you're heading for trouble. Are you 13.4%? Take action to get that number down right away. CHECK WITH YOUR HEALTHCARE TEAM Results of research studies done with thousands of people over many years suggest that a 7% HbA1c will cut the risk of getting complications almost in half. You can ask your doctor or healthcare team to help you find ways to reach that goal. Be sure you know your number and the date of your next test.

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