David, Here's another post from the diabetes discussion group and it begins to show
why ERGO and AMLN (for type II) may have a tough time of it, even if approved.
Pioglitizone is one of the second generation TZDs in advanced clinical trials. Its made
by Tekeda, JNJ's new partner in the far east. Another TZD, BRL49653, is made by
SBH, and its also in advanced trials. I think that BRL49653 is on a par with
Pioglitizone. Rezulin produced a 3% drop in HbA1c and this poster thinks that
Pioglitizone is "10 times better".
LGND used BRL49653 in its Nature study on mouse models of diabetes as well as
the Harvard study for treating liposarcomas. Targretin and ALRT268 were are a par
with BRL49653 for diabetes, and the rexinoids synergized with BRL49653 for the
treatment of diabetes as well as liposarcomas.
""Ken Wrote: Went to the Dr. a month ago. He put me on 200mg of rezulin
once/day. It
seems to me that my BG's are actually a little higher. Marginally
only. Is
this common as you start this medicine.
Going back tomorrow to try and figger out what to do.
<snip>
Hi Ken- most Doc's start at the lowest doseage (in this case 200 mg) to
see how YOUR system responds. I started out on 200mg & it was not
effective-- I asked if anyone was experiencing any degree of success
with that dose & there was not anyone on the list on a "Rezulin only"
treatment who is.
We upped the dose to 400 & it's somewhat better, considering my exercise
routine has bit the dust since nasty storms hit the Pacific Northwest
= <
I did a 6 month drug study on another Troglitazone drug (Pioglitazone)
that, as my Doc explained, is 10 times stronger than Rezulin. They were
doing 15 & 30mg doses.
I had excellent results with that particular drug, which yielded an A1c
of 5.7, in the final test.
This drug is in final FDA testing phases, and may be out on the market
in '98
Already in use in Japan for a few years now.
Fran" |
