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Biotech / Medical : Biotech for less than cash value
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To: Gary Mohilner who wrote (306)1/12/2008 10:12:33 PM
From: scaram(o)uche  Read Replies (2) of 684
 
For 37 years, we've been hearing about "cures" when a primary tumor is injected with an agent that elicits an anti-TNF response. Study the original work of Coley and the subsequent work of those like Morton et al.

If you catch a patient with an aggressive melanoma early, you can CURE that patient with surgical excision. If you were really desperate and stupid, you could CURE those same patients, at a high frequency, by injecting the cancer with BCG or something else that elicits a strong TNF response.

If you have a patient with metastatic disease, you can completely obliterate the primary with an agent that induces TNF, but the patient will die without any real benefit.

I like GNVC, but TNFerade will never work for a disease where the majority of advanced patients have metastatic disease. BFD if the injected primary goes poof...... you can't tailor an expensive medicine for a very small fraction of patients who might benefit (those who do not have metastases and where surgery to remove a primary is complicated by adjacent tissue). And some patients just flat out don't fit recruitment criteria...... one patient means squat.

Just over a year ago, he was diagnosed with inoperable pancreatic cancer -- the tumor was choking a major blood vessel.

"You usually don't last more than six months," Jordan said.

A small fraction of those with metastatic pancreatic Ca now live for five years post-diagnosis. It's not a pleasant five years, but Ms. Walsh is irresponsible.
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