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Biotech / Medical : SARS and Avian Flu
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From: JMarcus1/26/2008 12:12:56 PM
   of 4232
 
Cambodia - Inapparent infection suspected
Date: Fri 25 Jan 2008
Source: The China Post, Bloomberg report [edited]
<http://www.chinapost.com.tw/health/2008/01/25/140499/Bird-flu.htm>

Bird flu infection may go undetected in children
- ------------------------------------------------------
Bird flu infections in some children may be going
undetected because the virus causes mild or no
symptoms, researchers in Cambodia found,
indicating more human cases have probably
occurred than have been officially recorded.

A study of 674 people exposed to the deadly H5N1
avian influenza in 2 villages in Cambodia found 7
had developed antibodies against the virus,
indicating prior infection. All of the cases
occurred in people aged 4 to 18, the researchers
said in a study being presented at a conference
in Bangkok Thursday [24 Jan 2008].

The finding indicates more people, particularly
children and adolescents, may be contracting the
virus without developing the high fever and
severe pneumonia that's the hallmark of H5N1 in
people. A total of 3 of every 5 reported human
cases worldwide have been fatal. Higher rates of
milder disease might indicate the virus has found
a way to spread more efficiently in human.

- --
Communicated by:
ProMED-mail Rapporteur Mary Marshall

[This is an interesting observation, but
difficult to interpret in the absence of
quantitative data. The analysis is limited by the
fact that there have been few human cases of H5N1
avian influenza in Cambodia (since the beginning
of 2005 only 7 and all fatal). The study would
have been more productive if conducted in a
country with greater exposure to the disease.
The 100 percent fatality rate in Cambodia and the
occurrence of a low frequency of inapparent
infection in children is compatible with some
degree of inherent resistance of the majority of
the population to the H5N1 virus. - Mod.CP]
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