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Biotech / Medical : Elan Corporation, plc (ELN)

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To: fred hayes who wrote (9602)	3/1/2008 11:09:22 PM
From: IRWIN JAMES FRANKEL	Read Replies (5) of 10345

A few comments on Tysabri: I went in with my wife to see her neuro. My wife will be starting on T soon. Here are a few of the items that came out: - the local infusion center is seeing about 15% of patients develop anti-bodies to T, most by the second infusion, the rest by the 3rd - no patient has developed antibody reactions after the 3rd infusion - this center discontinues T in patients who react to treatments and do not use antihistamines to try and continue T treatment - most patients receiving T are very happy with the results - the center will be adding regular blood panels to monitor liver enzymes - there are still no available assays for PML and thus the regular survey questions and MRI's when suspect - PML can be read on MRI's and distinguished from MS lesions - they scoffed at the suggestion that T caused melanoma - the Center has not used Rituxan - they are excited about new treatments advancing that will change the management of MS ij

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