ACADIA Pharmaceuticals to Present Preclinical Data on ACP-104, ACP-105 and Its Muscarinic Discovery Program at Experimental Biology 2008 Meeting
Friday April 4, 9:00 am ET
SAN DIEGO--(BUSINESS WIRE)--ACADIA Pharmaceuticals Inc. (Nasdaq: ACAD - News), a biopharmaceutical company utilizing innovative technology to fuel drug discovery and clinical development of novel treatments for central nervous system disorders, today announced that the company will present preclinical data on its ACP-104 schizophrenia program, its ACP-105 Selective Androgen Receptor Modulator (SARM) program, and its muscarinic discovery program at the Experimental Biology 2008 Meeting to be held from April 5-9, 2008 in San Diego, California, and the related Satellite Symposium on Recent Advances in Muscarinic Receptor Pharmacology and Therapeutics to be held from April 4-5, 2008.
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ACP-104’s Pro-cognitive and Antipsychotic Actions in Animal Models are Based on Simultaneous Interactions with M1, 5-HT2A, and D2 Receptors
In poster presentations titled, “ACP-104 is a Unique Atypical Antipsychotic Agent with M1 Muscarinic Activity” and “In Vivo Receptor Occupancy of ACP-104 and Clozapine,” ACADIA researchers present new preclinical data on ACP-104, its novel drug candidate currently in Phase II development for the treatment of schizophrenia. The data show that ACP-104 demonstrates pro-cognitive actions in an animal model by a muscarinic M1 receptor dependent mechanism. ACADIA researchers also show that ACP-104 interacts with M1, 5-HT2A, and D2 receptors in vivo at doses that are effective in animal models of psychosis and cognition. In addition, the combined antagonism at 5-HT2A and partial agonism at D2 receptors in vivo suggests ACP-104 may produce antipsychotic activity with reduced extrapyramidal side effects. Furthermore, the findings that ACP-104 binds to and activates M1 receptors in vivo support the potential utility of ACP-104 as a pro-cognitive antipsychotic in the treatment of schizophrenia.
ACP-105, a Novel Non-Steroidal SARM
In a poster presentation titled, “In Vitro and In Vivo Profile of a Novel Tissue Selective, Orally Bioavailable Non-Steroidal Androgen Receptor Modulator,” ACADIA researchers present findings on ACP-105, a novel non-steroidal SARM. ACP-105 is shown to be as potent and efficacious as testosterone in in vitro assays without interaction at other hormone receptors. In addition, ACP-105 demonstrates potent anabolic effects on muscle and bone with minimal effect on prostrate in preclinical models.
AC-260584, a Novel and Selective Muscarinic M1 Agonist
In poster presentations titled, “Characterization of the Intrinsic Efficacies of M1 Muscarinic Receptor Agonists” and “Pharmacological Characterization of AC-260584, a Potent and Selective M1 Muscarinic Receptor Agonist,” ACADIA researchers describe the pharmacology of a novel, potent, and selective muscarinic M1 receptor subtype agonist. AC-260584 activates muscarinic M1 receptors in the brain and also has pro-cognitive actions in animal models. Further studies using a range of in vitro techniques reveal notable differences in the intrinsic activities of muscarinic M1 receptor agonists and demonstrate that allosteric agonists such as AC-260584 can have high intrinsic activity at muscarinic M1 receptors.
About ACP-104
ACP-104, or N-desmethylclozapine, is the major metabolite of clozapine that ACADIA is developing as a novel stand-alone therapy for schizophrenia. ACP-104 is designed to provide an atypical antipsychotic efficacy profile with the added potential benefit of enhanced cognition. ACP-104 combines M1 muscarinic agonism, 5-HT2A inverse agonism, and D2 and D3 dopamine partial agonism in a single compound and, therefore, uniquely addresses what ACADIA believes are the three most promising target mechanisms for treating schizophrenia. ACADIA has completed enrollment in a Phase IIb trial to evaluate the safety and efficacy of ACP-104 in patients with schizophrenia. ACADIA’s development program for ACP-104 has been supported in part by the Stanley Medical Research Center.
About ACP-105
ACP-105 is a non-steroidal and selective androgen receptor agonist. ACP-105 is part of a class of molecules referred to as selective androgen receptor modulators (SARMs). SARMs may advance the standard of treatment for a variety of disorders including muscle-wasting conditions and osteoporosis, with fewer side effects as compared to current treatments based on testosterone replacement. ACP-105 has exhibited promising pharmacological properties and a favorable safety profile in preclinical testing.
About ACADIA Pharmaceuticals
ACADIA is a biopharmaceutical company utilizing innovative technology to fuel drug discovery and clinical development of novel treatments for central nervous system disorders. ACADIA currently has five mid-to-late stage clinical programs as well as a portfolio of preclinical and discovery assets directed at diseases with large unmet medical needs, including schizophrenia, Parkinson’s disease psychosis, sleep maintenance insomnia, and neuropathic pain. All of the drug candidates in ACADIA’s product pipeline emanate from discoveries made using its proprietary drug discovery platform. ACADIA’s corporate headquarters is located in San Diego, California and it maintains research and development operations in both San Diego and Malmö, Sweden. |
