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Biotech / Medical : Infinity Pharmaceuticals

INFI 0.0160

-4.8%

Sep 29 5:00 PM EST

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To: Mike McFarland who wrote (169)	5/5/2008 9:38:17 AM
From: Mike McFarland	of 210

Infinity Highlights Promising Preclinical Hedgehog Data and Announces First Quarter Financial Results Heat Shock Protein 90 Program Continues to Advance Toward Potential Registration Trial investor.ipi.com Retaspimycin is currently in four ongoing clinical trials: the expansion portion of a Phase 1 trial in patients with GIST, the Phase 2 portion of a Phase 1/2 trial in patients with NSCLC, a Phase 2 trial in patients with hormone-resistant prostate cancer, and a Phase 1b trial of retaspimycin in combination with Taxotere(r) (docetaxel). The expansion portion of the Phase 1 trial of retaspimycin in patients with GIST, designed to further characterize the safety and biological activity of retaspimycin, has enrolled over 20 patients at the recommended Phase 2 dose and schedule of 400 mg/m2 administered twice weekly for two weeks, followed by one week off treatment. Several patients are continuing to receive treatment on study. Infinity expects to report data from this expansion phase at the ASCO Annual Meeting in May 2008, and pending analysis of the data and ongoing consultation with advisors, key opinion leaders, and regulatory authorities, expects to launch a registration trial of retaspimycin in refractory GIST in the third quarter of 2008.

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