Teva is up *1.6B* or so in market cap today on their p3 hit for a PD drug.
biz.yahoo.com
Not much meat in the only acad data release I could find on pimavanserin for PD:
<<<ACADIA Pharmaceuticals to Present Data from Its Phase II Trial with Pimavanserin for Parkinson's Disease Psychosis at the 60th American Academy of Neurology Annual Meeting
SAN DIEGO--(BUSINESS WIRE)--April 16, 2008--ACADIA Pharmaceuticals Inc. (Nasdaq:ACAD), a biopharmaceutical company utilizing innovative technology to fuel drug discovery and clinical development of novel treatments for central nervous system disorders, today announced that the company will present data from its previously reported Phase II trial with pimavanserin for Parkinson's disease psychosis (PDP) at the 60th American Academy of Neurology Annual Meeting on April 16, 2008 in Chicago, Illinois.
In a poster presentation titled "A Double-Blind, Placebo-Controlled, Dose-Escalation Trial of Pimavanserin in Parkinson's Disease and Psychosis," ACADIA summarizes data from its double-blind, placebo-controlled Phase II clinical trial that was designed to evaluate the tolerability, safety, and efficacy of pimavanserin in 60 patients with PDP. The primary endpoint of the study was met as pimavanserin did not worsen parkinsonism symptoms that affect activities of daily living and motor function, as measured by the Unified Parkinson's Disease Rating Scale (UPDRS). The use of pimavanserin was shown to be safe and well tolerated. Patients treated with pimavanserin also showed improvements in psychosis scores. The data suggest that pimavanserin, a selective serotonin 5-HT2A inverse agonist that does not block dopamine D2 receptors, may provide antipsychotic benefit to patients with PDP without adversely affecting motor function. In contrast, antipsychotics used off-label for this condition are generally not well tolerated by patients with Parkinson's disease at doses required to achieve antipsychotic effects.>>>
Any good reason to think this isn't a long shot? acad full steam ahead here with 2 phase III's ongoing.
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