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Biotech / Medical : Protein Design Labs (PDLI): Stock strong
PDLI 2.4700.0%Jan 18 4:00 PM EST

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From: tom pope6/18/2008 10:30:48 AM
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More from Merrill, on the bap news

Good for PDL, gauging potential impact of bapineuzumab
We believe that PDL stands to receive royalties on any sales of Wyeth-Elan’s
bapineuzumab, the humanized monoclonal antibody in phase lll development for
the treatment of Alzheimer’s disease which could be a blockbuster. We currently
have no estimates in our royalty model, but with encouraging top-line phase ll
data reported, we estimate the hypothetical current value of risk adjusted future
royalties at about $0.10 to $0.67 per share based on various scenarios. Maintain
Buy.

Potential upside to current estimates
We estimate that PDL could receive a 3% royalty on any sales of bapineuzumab,
which could potentially launch in the 2010-2011 time-frame. In the valuation
model, we estimate an NPV (at launch) of bapineuzumab sales in 2011-2014
ranging from about $3.1bn to $5.2bn, representing an NPV (at launch) of potential
royalties to PDL of about $94-157mn. We then risk adjust the NPVs and discount
back three years at 10%. Using risk adjustments of 20-80%, we estimate those
potential royalties represent current upside of about $0.10 to $0.67 per share. For
example, using our pharma team’s estimates of $1bn in 2012 and 40% probability
of launch, we estimate that the antibody means about $0.27 of current value
(upside to the stock). Our model only includes sales estimates through 2014 as
the Queen patents expire near the end of that year. (See model at page 2).

Maintain Buy
We believe PDLI stock is undervalued at current levels, as we believe the Street
is underestimating the prospects of the planned spin-out of a separate biotech
company. There could also be upside to estimates for the planned royalty holding
company thanks to antibodies such as bapineuzumab.
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