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Pastimes : Heart Attacks, Cancer and strokes. Preventative approaches
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From: LindyBill8/9/2008 4:59:49 PM
   of 39288
 
Statins
[From the TYP site]
These are popular prescription drugs that lower LDL cholesterol up to 60% by increasing liver uptake of cholesterol particles. Triglycerides are also reduced moderately and HDL cholesterol increased a few points. Advantages: potency and convenience. Data consistently show a reduction in heart attack risk of about 30% over 5 years of treatment. There may be reductions in colon cancer, Alzheimer's, and stroke, as well. Side-effects include muscle damage and liver problems (evidenced by elevations in liver tests by blood draw) which occur in 1-2% of people. Much more commonly, vague muscle aches and weakness occur. The statin agents are, from most potent to least potent:

* Crestor (rosuvastatin)
* Lipitor(atorvastatin)
* Zocor (simvastatin)
* Pravachol (pravastatin)
* Mevacor (lovastatin)
* Lescol (fluvastatin)

The principal difference among the various agents is potency. For example, if your starting LDL cholesterol is 240 mg/dl, a potent agent will likely be required to reduce LDL to your target (usually 100 mg/dl or less; 60 mg/dl in the Track Your Plaque program). If your starting LDL is 135 mg/dl, then a less potent agent can be used effectively. Statins are often combined with other agents. For example:

* In the Track Your Plaque approach, a statin agent is frequently combined with niacin (usually as prescription Niaspan) because of the powerful synergistic effect of the combination, including reduction in heart attack risk of up to 90%.
* Advicor is a combination of a statin and niacin (see below).
* Caduet is a combination of atorvastatin and a blood pressure-lowering drug, Norvasc (amlodipine).
* Vytorin is a combination of atorvastatin and ezetimibe
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