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Pastimes : Heart Attacks, Cancer and strokes. Preventative approaches
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To: John Carragher who wrote (1231)9/22/2008 4:56:26 PM
From: jrhana  Read Replies (1) of 39297
 
<How the Modern Diet Causes Inflammation
Excessive ingestion of calorie-dense, easily digestible foods causes abnormal surges in blood glucose and triglyceride levels.[11–13] This bolus of energetic substrate overwhelms the metabolic capabilities of the mitochondria in the overnourished muscle and adipose tissues. Glucose and free fatty acids flood the Krebs cycle, stimulating an excess of the reduced form of nicotinamide adenine dinucleotide production, which outstrips the capacity of oxidative phosphorylation and drives the transfer of single electrons to oxygen, creating free radicals such as superoxide anion.[17] Post-prandial glucose excursion correlates directly with the ensuing increase in free radicals (Fig. 2). This post-prandial oxidant stress acutely triggers atherogenic changes, including increases in low-density lipoprotein oxidation, sympathetic tone, vasoconstriction, and thrombogenicity.[5,17] Meal-induced inflammation is evidenced by immediate increases in C-reactive protein, cytokines, and endothelin-1 (Fig. 3).[3,17] Even hyperglycemic spikes induced artificially using intravenous glucose infusions in lean nondiabetic individuals have been shown to markedly increase free radical generation.[18]>

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