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Biotech / Medical : Elan Corporation, plc (ELN)

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To: tom pope who wrote (10084)	2/3/2009 8:56:03 AM
From: pgo-neil	Read Replies (1) of 10345

Hi Tom, You are welcome. One other point I forgot last night... Plex is not without its problems. The recent PML related death after PLEX is likely more IRIS related [Immune Reconstitution Inflammation Syndrome]. So, with a few more datapoints, the Plex cycle might be optimized to remove as quickly as possible without triggering IRIS. THe following article gives some background on IRIS and its likely triggers: aidsmap.com However AIDS JCV and PML may not be an accurate model for MS/Ty/immune system treatmenets results. So the rough numbers [about as accurate as one pass of the dice at a crap table] are: Between 1 in 1000 and 1 in 6000 PML at 17 months About 25% risk of IRIS after PLEX Maybe death rate from PML [including IRIS] could still get to about 1 in 10K. This would be a lot easier for patients and Drs. to look at than 1 per thousand. I doubt the data will ever support risk of death at 1 in 100K, so PML remains on the label [and it is black]. Life is never dull on the ELN roller-coaster, graham --

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