SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Ligand (LGND) Breakout!
LGND 198.070.0%12:50 PM EST
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: james who wrote (10142)10/25/1997 10:34:00 PM
From: Henry Niman  Read Replies (1) of 32384
 
james, I'm not sure where to start with your comments. LGND has a very strong patent position on most of their drugs (over 150 issued and 200 pending). Publishing a patented structure actually makes it more difficult for others to protect, because the publication puts the structure in the public domain.

Targretin has been in clinical trails for 3 years now. The Nature article came out 8 months after pivotal Phase III Targretin trials (for CTCL) were announced. These trials are scheduled for completion next year. Targretin will probably be on pharmacy shelves in 1999 and LGND's phase II European trial for type II diabetes is finishing up.

I assume that you are way behind the curve on LGND. In fact the relationship between RXRs and PPARs (heterodimer formation) was published by Ligand scientists in 1992, before LGND even went public. LGND discovered RXRs and in 1992 their natural ligand, 9-cis retinoid acid, the first polypeptide hormone to be discovered in over 25 years, was described.

The Nature article is old news to most. If fact the announcement of the diabetes indication was made Sept 12, 1996, the same day that this thread began, not in the March, 1997 Nature paper. Check out the past 10,000 post. I think you have missed a few critical details.
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2026 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News