Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 201.15

-1.3%

Jan 23 9:30 AM EST

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To: squetch who wrote (10198)	10/27/1997 10:42:00 AM
From: Joe Wesley	Read Replies (1) of 32384

Hi Stan: BioCentury had another article on the lly-lgnd deal this morning. I don't know if this has been discussed however. Jose Caro Lilly VP of endocrine research noted the Am. Diabetes Association and World Health Organization among others about two months ago endorsed a new diagnostic criteria for diabetes. Lowering minimum fasting blood glucose to 126mg/dl from 140mg/dl, meaning that many more patients with earlier stage disease now will be considered diabetics. This is one of four factors that could combine to increase the demand for interventions at stages that don't require insulin (and in turn necessitated the lgnd deal). Caro explains before the onset of diabetes, patients develop insulin resistance, in which the pancreas develops plenty of insulin, but the body tissues ignore it. He goes on to say oral Targretin (in Phase 2) for type 2 diabetes could be marketed as a drug alone or in combination with PPAR agonists as treatment of insulin resistance with the goal of preventing diabetes. Amateur

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