SWOOP DOWN LIKE A GIANT CONDOR
To: Street Walker who started this subject 2/21/2004 4:08:43 PM
From: ByrnesSithLordFraud of 5266
TRUTHSEEKER, PROUD MEMBER OF C.O.N.D.O.R Citizens Opposed to Nasal Destruction of Olfactory Receptors
gojistomp.org
SWOOP DOWN LIKE A GIANT CONDOR
It's entirely possible that it could be
recalled one day! Think about it! That's never happened to a
homeopathic remedy...ever!
Think about how the media and Feds (FDA)
could swoop down on this like a Giant Condor. On and on and on.
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Zicam® Induced Anosmia
Bruce W. Jafek, MD
Miriam Linschoten, Ph. D.
Bruce W. Murrow, MD, Ph. D.
Denver, CO
Introduction: Zinc is extensively utilized throughout the body,
supporting the activity of approximately 100 enzymes, the im-
mune system, wound healing, the senses of taste and smell, and
DNAsynthesis. Zinc supports normal growth and development.
The deleterious effects of both deficiency and toxicity (acute and
chronic) are described. Beneficial zinc absorption takes place via
enteral, parenteral, or cutaneous routes. Direct application to the
olfactory epithelium, on the other hand, has long been known to
be toxic, producing anosmia. This toxicity is thought to be due to
the direct effect of the divalent zinc ions on olfactory receptor
cells. Apparently overlooking this toxicity, however, intranasal
Zicam® (zinc gluconate) has recently been recommended as a
treatment for the common cold.
Methods: We will present a series of patients with post- Zicam®
anosmia. The mechanism of drug toxicity will be analyzed.
Results: While interindividual variation in drug response and
drug toxicity is apparent, post- Zicam® anosmia appears to be
dose- related and permanent.
Conclusion: Zinc ions remain toxic to human olfactory epithe-
lium, and continued reports of total, probably irreversible,
anosmia, can be expected as long as intranasal zinc gluconate gel
(Zicam®) continues to be used. The recent extension of the use
of Zicam® to the pediatric age group is particularly alarming
since this group is less likely to be able to describe the anosmia.
Immediate discontinuation of the use of intranasal zinc recom-
mended.
"Those who do not learn from history are doomed to repeat it."
— George Santayana (1863- 1952), noted philosopher
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Complaints About Popular Cold Medicine
Jeffrey Schaub
Watch the Video kpiximg.dayport.com
Kay Henley's world is missing something she used to take for granted.
"I noticed I couldn't smell my flowers," she said. "I can't smell brewed coffee."
Vivid scents became just a memory when she suddenly lost her normal ability to smell. It's the result, she claims, of using a popular over-the-counter cold remedy called Zicam.
"It was recommended by someone I worked with," Henley said. "Everyone was getting colds."
Zicam is a nasal spray that promises to shorten the duration of a common cold. It's sold over-the-counter in drug stores and supermarkets across the country. But now, a growing number of users are claiming Zicam also destroyed their ability to smell.
Dr. Terry Davidson has seen the symptoms first hand at U.C. San Diego's Nasal Dysfunction clinic. He believes the patients he's seen inadvertently inhaled the product into their upper nasal passages, where the olfactory receptors are located. That's a serious risk, he says, because of Zicam's active ingredient, a form of Zinc.
"You put Zinc on a receptor, you effectively kill the receptor," Davidson said. "It's like pouring acid on an open wound."
But in a written statement, the manufacturer of Zicam defends its safety, saying "In no clinical trial of intranasal zinc gluconate gel products has there been a single report of lost or diminished olfactory function."
But that claim is now being challenged by several lawsuits. And CBS 5 has learned the Food and Drug administration is also reviewing allegations about Zicam.
Even though Kay Henley has quit using Zican she's been told that her loss of smell could be permanent -- a prospect she believes stinks.
"I wouldn't touch it with a ten-foot pole," she said. "It's not worth the chance of this happening."
» 02-19-2004
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User Says Zicam Robbed Her Of Sense Of Smell
FDA Investigating Zicam Gel, Which Is Applied Directly In Nose
POSTED: 2:02 pm MST February 5, 2004
UPDATED: 2:30 pm MST February 6, 2004
A nationally advertised cold product that may now be in your family medicine cabinet could rob you or your children of the ability to smell -- to smell gas or a fire in your home or to enjoy the aroma and taste of your food, 7NEWS Investigator John Ferrugia said.
Video
Hear How One User Says Zicam Destroyed Her Smell
Discuss Zicam With Others
Contact The Investigators
7NEWS began investigating Zicam a month ago after one of our own employees said she had lost her sense of smell after using it. Now the Food and Drug Administration has begun its own investigation of complaints around the country.
Linda Bayley is finally coming to the realization that she has lost her sense of smell. According to the doctors at the University of Colorado Center for Taste and Smell Disorders, it's not likely she will get it back.
"You just do not have enough receptor cells to know what you are smelling," Dr. Miriam Linschoten told Bayley.
"You know, looking at your whole life and not being able to smell and not being able to have flavors, all because you used a product. I mean, it's just not fair, it's just not fair," Bayley said, sobbing.
Bayley and other consumers around the country claim that that product is Zicam gel, which contains zinc gluconate and is applied in the nose.
Bayley is one of more than a dozen patients Dr. Bruce Jafek has either examined personally or referred to others when they reported the loss of smell after using Zicam Intranasal Zinc.
He is now preparing to publish his findings.
"At least in the majority of the patients we have seen, there hasn't been a return of function," Jafek said.
Jafek says Bayley's experience with Zicam mirrors the stories of others who have used the Zicam compound and lost their sense of smell.
"I put it up my nose, like you are supposed to ... you don't inhale it, and you are supposed to hold your nostril closed ... and the burning," Bayley said. "I had the most intense burning sensation that was just ... I mean, it threw me for a loop, it was so bad. "
The next day, as she picked up her cat, she realized she had a serious problem.
"I was cleaning her cat box and I realized I couldn't smell. I couldn't smell the cat box," Bayley said.
And then she couldn't smell her favorite food -- pumpkin pie.
"When I ate a piece I couldn't taste it. It was just bland mush," Bayley said.
Jafek says the problems of zinc compounds used in the nose are well-known -- they began in the 1930s when people were trying to prevent polio.
"It did not work for polio but was found that about 10 percent of the people lost their sense of smell as a result of the zinc application ... permanently," Jafek said. "Closer to the present day, then it has been used in animal experiments, particularly in fish and rodents, mice and rats, in which the purpose was to put zinc into the nose and destroy the sense of smell."
But in those cases, a compound of zinc sulfate is used. Zicam contains zinc gluconate. The manufacturer, Matrixx Initiatives, says there is a significant difference in the compounds.
"Not in my mind. The idea in terms of the zinc treatment of a cold is that you want to get the zinc ion into the nose where it will have anti-viral activity," Jafek said.
Matrixx declined an on-camera interview but told 7NEWS in an e-mail: "Statements alleging that intranasal Zicam products cause anosmia (loss of smell) are completely unfounded and misleading."
The company says, "The safety and efficacy of zinc gluconate for the treatment of symptoms related to the common cold have been well established in two double-blind, placebo-controlled, randomized clinical trials."
It also noted, "a multitude of environmental and biologic influences are known to affect the sense of smell."
Both Jafek and Linschoten examined the company's studies and say they simply do not address the safety question.
"Since they didn't test for smell loss before and after, no (these studies) are not relevant," Linschoten said.
"There's no doubt in my mind there's a cause and effect just because I took it, it burned like crazy, the next day I didn't have any sense of smell," Bayley said.
For Bayley, the thought has brought anger, frustration, and an emotional sense of loss.
"You know, the people who are closest to you, your family, it's not something you think about, but being able to smell them -- my little infant, my baby cousin. I can't smell babies anymore," Bayley said. "That human closeness. It's a connection. It's a connection lost."
Zicam makes several products. Only one is in question: the nasal gel or swabs for your nose, which contain zinc gluconate and is listed on the packaging. This does not apply to lozenges or other Zicam products.
In addition to the FDA investigation of complaints, there have now been four separate lawsuits filed against the maker of Zicam. The company has denied liability.
Another nationally known company makes a zinc spray one that people may use. There are reports of similar loss of smell with this product as well.
7NEWS will have more on this story Friday at 10:15 p.m.
Additional Resources
Contact The Investigators About This Story
Discuss Zicam With Others
Zicam's Web site
Rocky Mountain Taste and Smell Center at the University of Colorado Medical Center
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