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 PolyMedix Receives United States Patent for Angiogenesis Inhibitor Compounds
 
 Jul. 15, 2009
 Business Editors/Biotech Writers
 
 RADNOR, Pa.--(BUSINESS WIRE)--Jul. 15, 2009--PolyMedix, Inc. (OTCBB: PYMX,
 polymedix.com), an emerging biotechnology company developing acute care
 products for infectious diseases and acute cardiovascular disorders, announced
 today that the United States Patent and Trademark Office issued a patent
 assigned to PolyMedix relating to angiogenesis inhibitors. The patent, number
 7,553,876, entitled "Polycationic Compounds and Uses Thereof," relates to
 therapeutic uses of PolyMedix compounds for inhibiting angiogenesis.
 
 Angiogenesis is a process involving the growth of new blood vessels. The
 abnormal growth of new blood vessels is associated with many diseases,
 including age-related macular degeneration (AMD), the most common form of
 blindness in the elderly, cancers, and inflammation. Inhibiting abnormal
 angiogenesis may be useful therapy for these conditions. Lucentis(r) and
 Macugen(r) are two products currently approved for treatment of AMD.
 PolyMedix's angiogenesis inhibitors may have a mechanism of action distinct
 from compounds that only inhibit VEGF (vascular endothelial growth factor).
 
 "This is an exciting accomplishment for PolyMedix. This patent represents
 the first allowance from our applications relating to angiogenesis inhibition,
 and another compelling example of the efficiency and capabilities of our drug
 discovery approach," commented Nicholas Landekic, President and Chief Executive
 Officer.
 
 About PolyMedix, Inc.
 
 PolyMedix is a publicly traded emerging biotechnology company focused on
 the development of novel drugs and biomaterials for the treatment of infectious
 diseases and acute cardiovascular disorders. PolyMedix's compounds are based on
 biomimetics: non-peptide small molecule drug candidates that mimic the activity
 of proteins. The Company's antibiotic compounds, including PMX-30063 - small
 molecule mimetics of human host-defense proteins - have a mechanism of action
 distinct from those of current antibiotic drugs, a mechanism which is intended
 to make bacterial resistance unlikely to develop. The Company's goal is to
 develop these as rapidly acting antibiotics for serious systemic and local
 infections. The Company plans to continue the development of polymeric
 formulations as antimicrobial biomaterials, which can be used as additives to
 paints, plastics, and textiles to create self-sterilizing products and
 surfaces. The Company's heptagonist compounds, including PMX-60056, reverse the
 activity of both heparin and Low Molecular Weight Heparins, with the goal of
 developing an antagonist drug that is safer and easier to use than currently
 approved therapy for heparin. For more information, please visit PolyMedix on
 its website at www.polymedix.com.
 
 Lucentis(r) is a registered trademark of Genentech, Inc.
 
 Macugen(r) is a registered trademark of Eyetech, Inc.
 
 This press release contains forward-looking statements made pursuant to the
 safe harbor provisions of the Private Securities Litigation Reform Act of 1995
 that involve risks, uncertainties and assumptions that could cause PolyMedix's
 actual results and experience to differ materially from anticipated results and
 expectations expressed in these forward looking statements. PolyMedix has in
 some cases identified forward-looking statements by using words such as
 "anticipates," "believes," "hopes," "estimates," "looks," "expects," "plans,"
 "intends", "goal", "potential," "may," "suggest," and similar expressions.
 Among other factors that could cause actual results to differ materially from
 those expressed in forward-looking statements, PolyMedix's compounds may not
 enter or successfully complete clinical testing or be granted regulatory
 approval to be sold and marketed in the United States or elsewhere. A more
 complete description of these factors is included in PolyMedix's filings with
 the Securities and Exchange Commission. You should not place undue reliance on
 any forward-looking statements. PolyMedix undertakes no obligation to release
 publicly the results of any revisions to any such forward-looking statements
 that may be made to reflect events or circumstances after the date of this
 press release or to reflect the occurrence of unanticipated events, except as
 required by applicable law or regulation.
 
 CONTACT:  PolyMedix, Inc.
 Lona Cornish, 484-598-2340
 lcornish@polymedix.com
 or
 The Investor Relations Group
 Investors: Erika Moran
 emoran@investorrelationsgroup.com
 Media: Janet Vasquez
 jvasquez@investorrelationsgroup.com
 212-825-3210
 
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