Hi folks.
I've been meaning to get around to introducing my self and posting whatever relevant information may help people who are thinking about trying the Rick Simpson method. As my mind is still not as clear as i would like (not from the oil) I'm hopeful Peanutbutter will clarify or correct any info I messed up. More will be coming soon. It's never going to be perfect so for now . . .
Hello,
I'm Greg Piasecki, A 41 year old male and a qualified Michigan Medical MJ Patient and President of Oakland County NORML out here in Michigan.
Short version - May 12, 2009 I had a Grand Mal seiziure, lost consciousnous and found out I have stage IV GBM (primary). I have had no other known incidents of cancer and no previous symptoms.
A golf ball sized mass Approx. 3.65 cm in dia and deep in the right side. 66% resected May 15th. In ICU through 22nd of May, released home May 26th.
30 treatments of radiation and chemo with 200 mg of Temadar/ day 5 days/ week began June 2 with the final radiation treatment July 14th . I am currently in a break period waiting to start my next course of chemotherapy with 400 mg of Temadar for 5 days on with 25 off/ month for approximately a year. A follow up MRI is scheduled for sometime in August.
I don't have the original emergency room CT and MRI in my possession but i do have my baseline CT they took 4 days before chemo and rad began and providing access to my medical records is easy enough.
Through my involvement with Oakland County NORML I had been reading and sharing various cannabinoid research pieces starting with the Compultense University studies on GBM’s
Beginning with the early study in 2004:
ScienceDirect - Neuropharmacology : Hypothesis: cannabinoid therapy for the treatment of gliomas?
Hypothesis: cannabinoid therapy for the treatment of gliomas?
Guillermo Velasco, Ismael Galve-Roperh, Cristina Sánchez, Cristina Blázquez and Manuel Guzmán,
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Avenida Complutense, sn, 28040, Madrid, Spain
Received 21 January 2004;* Revised 25 March 2004;* accepted 22 April 2004.* Available online 10 July 2004.
Abstract
Gliomas, in particular glioblastoma multiforme or grade IV astrocytoma, are the most frequent class of malignant primary brain tumours and one of the most aggressive forms of cancer. Current therapeutic strategies for the treatment of glioblastoma multiforme are usually ineffective or just palliative. During the last few years, several studies have shown that cannabinoids—the active components of the plant Cannabis sativa and their derivatives—slow the growth of different types of tumours, including gliomas, in laboratory animals. Cannabinoids induce apoptosis of glioma cells in culture via sustained ceramide accumulation, extracellular signal-regulated kinase activation and Akt inhibition. In addition, cannabinoid treatment inhibits angiogenesis of gliomas in vivo. Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas.
Bring us 5 years into the future and we arrive here:
Journal of Clinical Investigation -- Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
Published in Volume 119, Issue 5 (May 1,2009)
J. Clin. Invest. 119(5): 1359-1372 (2009). doi:10.1172/JCI37948.
Copyright © 2009, The American Society for Clinical Investigation
Research Article
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that ?9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2a (eIF2a) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
Add in the nueroprotective, anti-inflamitory, anti-seisiure, apatite stimulation, and anti-nausea properties, blood pressure and blood sugar modulation on top of being able to finally sleep and increasing my odds of sticking around for my family and friends.
Through the wonderful help of some amazing people*may 23rd and speaking with my most of my doctors I started taking an alternative cannabis treatment commonly referred to as the ‘Rick Simpson method’ before getting out of ICU and Run from the cure to my family.
There are 2 points to this insanely long post, (Hope I put it in the right spot).
Firstly, After surgery, they didn’t know if I was going to make it to September 2009. After only 9 weeks of conventional therapy AND the Simpson Oil I appear to be farther along then ANY of my doctors or nurses ever expected. Can’t wait for the next MRI when they are scratching their heads looking for more cancer bits.
Secondly, I’m looking for researchers, physicians, etc. that can somehow use my info. Michael’s older posts pointed to a doc that didn’t pan out. Since then, he and a few others, thankfully, sent me here! If someone can use my info let's do this, that's the whole point. I'm guessing all I need to do is sign some HIPPA forms and that will provide access needed?
General info and background here:
caringbridge.org
Take care and thanks for being out there.
Greg Piasecki
greenpassion.org
To be clear, I may take a bit longer to get back with folks then normal right now. Peanutbutter is free and encouraged to discuss anything about my interesting jouney if he would like.
Thanks, More to come soon. |
