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Biotech / Medical : Biotech News

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From: Doc Bones8/15/2009 2:40:50 AM
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Celiac Disease Insights: Clues to Solving Autoimmunity

Study of a potentially fatal food-triggered disease has uncovered a process that may contribute to many autoimmune disorders

By Alessio Fasano
August 2009 Scientific American Magazine

Key Concepts

Celiac disease (CD) is an autoimmune disorder triggered by ingestion of gluten, a major protein in wheat, or of related proteins in other grains.

Research into the root causes indicates that the disorder develops when a person exposed to gluten also has a genetic susceptibility to CD and an unusually permeable intestinal wall.

Surprisingly, essentially the same trio—an environmental trigger, a genetic susceptibility and a “leaky gut”—seems to underlie other autoimmune disorders as well. This finding raises the possibility that new treatments for CD may also ameliorate other conditions.

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scientificamerican.com
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