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Biotech / Medical : Biotech News
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To: tom pope who wrote (6681)11/3/2009 1:59:50 PM
From: Biotech Jim  Read Replies (1) of 7143
 
Tom-

All three of the tests should be used if one wants the entire picture. Vit D is the parent, but 2 metabolic transformations have to take place for full activity. The liver has the 25 hydroxylase enzyme that puts a hydroxyl on the 25 position. then, this 25-hydroxy Vit D goes via the blood stream to the kidney where the 1 alpha hydroxylase resides. This enzyme then makes the product 1,25-dihydroxy Vit D, which is the most biologically active form of Vit D in terms of its calcium-related activities. If you want only 1 test, use either the Vit D or the 1,25-dihydroxy Vit D test.

I used to work with Hector DeLuca in the University of WIsconsin Biochemistry department where a lot of this work was discovered. Quite an exciting time back then, and thanks to the National Science Foundation that I received the summer undergraduate fellowship. BTW, Mike Hollick was at that time finishing up his PhD work with Hector, and today Mike is one of the key clinicians studying Vit D.

BJ
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