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Biotech / Medical : Biotech & Pharma.T.A,

BIB 76.73

+1.7%

Nov 17 4:00 PM EST

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To: Jibacoa who wrote (2804)	5/3/2010 10:34:06 AM
From: Jibacoa	Read Replies (2) of 3722

RPTP is still up 34.69% with volume of > 636Ks already > 7x its ADV bigcharts.marketwatch.com It announced positive PIIa results from its study of delayed-release cysteamine bitartrate in 11 adolescent patients with non-alcoholic steatohepatitis, which is believed to affect 5% to 11% of the U.S. population. The results were presented at the Digestive Disease Week 2010 conference in New Orleans. Patients showed a marked decline in ALT levels during the treatment period with 7 of 11 patients achieving a greater than 50% reduction and 6 of 11 reduced to within normal range. AST levels also showed significant improvements with patients averaging 41% reduction by the end of the treatment. The reduction in liver enzymes was largely sustained during the 6 month post-treatment monitoring phase. Other important liver function markers showed positive trends. Levels of cytokeratin 18 decreased by an average of 45%. Adiponectin levels increased by an average of 35% during the treatment period. (Reduced adiponectin levels are thought to be a marker of the pathogenesis and progression of NASH.) Delayed-release cysteamine bitartrate demonstrated a strong, favorable safety profile, with mean gastrointestinal symptom scores of 1.1 at baseline and 0.7 after 6 months of treatment. Apparently there is now changes from the plans of last year of liquidating the company and distributing its assets.<g> bigcharts.marketwatch.com Bernard

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