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Biotech / Medical : Ionis Pharmaceuticals (IONS)
IONS 72.94-1.6%1:54 PM EST
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To: biofisher who wrote (4587)8/4/2010 3:53:51 PM
From: tuck  Read Replies (1) of 4676
 
For the general population of hypercholesterolemia patients on statins, incidence of persistent ALT/AST 3x ULN is much lower, like 1%. In HFH patients on statins, about twice that, probably because they take a higher dose than most hypercholesterolemia patients and there's a dose dependent effect on liver enzymes.

Cheers, Tuck
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