Shareholders ------------
Pfizer..............1,862,093 10.1 0 09/30/09
Midsummer CapL.L.C..1,201,038 6.5 230,733 10/29/09
Orbis InvestLimited.. 949,582 5.1 0 09/30/09
RA Capital M...LLC....898,911 4.9 -12,019 06/30/10
Ashton (Paul).........430,091 2.3 0 09/30/09
Palo Alto Invest......338,734 1.8 150,640 06/30/10
Morgan Stanley........274,233 1.5 0 06/30/10
Janney Montgomery.....106,500 0.6 106,500 06/30/10
The Pennsylvani.......106,500 0.6 106,500 06/30/10
Freedman (Lori)........96,423 0.5 31,616 09/30/09 Vanguard Exten.........19,390 0.1 900 06/30/10
John Hancock F..........2,379 0.0 2,379 02/28/10 Ownership data based on most recent publicly available data according to Thomson Reuters.
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