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Biotech / Medical : Ligand (LGND) Breakout!

LGND 199.53

+1.5%

3:59 PM EST

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To: Andrew H who wrote (10992)	11/12/1997 2:41:00 AM
From: squetch	Read Replies (1) of 32384

Here is some info from a Rezulin ad I saw. This is from the fine print part and I don't know if this "caution" section was pre or post FDA letter. During all clinical studies in NorthAmer (n=2510) a total of 20 Rez-treated patients were withdrawn for treatment b/c of liver fx test abnormalities. 2/20 developed reversible jaundice. Both had biopsies which were consistent w/ idiosyncratic drug reaction. In premenopousal anormulatroy patients w/ insulin resistance, Rez may result in resumption of ovulation. hemogloblin decreased 3-4% compared w/ a 1-2% decrease in placebo. Change occured in first 4-8 weeks. Levels stabilized and remained unchanged(up to two years in my recollection is correct Yes a big IF) Risk of hypoglycemia if used in combo w/ insulin or oral hypoglycemic agents Recomend insulin not Rez during pregnancy.

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