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Biotech / Medical : PSDV - pSivida Limited

PSDV 1.220

+14.0%

Mar 29 4:00 PM EDT

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To: kenhott who wrote (361)	2/4/2011 1:31:42 PM
From: John McCarthy	of 421

Hi Ken Great Insight. And I sincerely mean that. More importantly you may be RIGHT about what really caused the overal Iluvien improvements. That said - I see it different - w/o the benefit of anything to corroborate my thoughts. My nutshell is this: (a) DME is a BACK-DOOR problem. (b) The daily F-steriod fixes the BACK-DOOR. (c) In doing so (b) it (F-steriod) creates a FRONT-DOOR problem negating the BACK-DOOR fix/benefits. (d) Surgery fixes the FRONT-DOOR problem allowing the BACK-DOOR fix to be effected. (e) If catarack surgery alone was the major/distinct beneficial effect against DME (which it may be) then it really s/b considered as a FIX against DME even when the patient does not have cataracks. ----- I realize these thoughts (credibly) might be deemed stupid (and appropriately so) but I can't change the way my mind works -g- hence my response. My take-away on this "learned science" is that continued use (day after day) of the F-steriod leads to cataracks. And I bet nobody knew that - science-wise. (And kinda surprized it didn't show up in the critters they pre-cliniced it on) Also, I was wondering silently if there might not be a better steriod candidate out there than the F-Steriod. Finally - I think the F-steriod kicks in "the catarack problem" shortly after the 6th week. Again - strange how this did not show up in critter testing. The FDA options are: (1) Burn out the back of the eye. -or- (2) Spend approx. $25-$30 year when all costs are considered on Lucentis. Shame on me - but I am still wearing my no brainer t-shirt. regards John

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