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Biotech / Medical : Agouron Pharmaceuticals (AGPH)

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To: Oliver & Co who wrote (2768)11/13/1997 9:45:00 PM
From: Joe E.  Read Replies (2) of 6136
 
Thanks for your note on NIH guidelines.
Re: <<I start patients on treatment asap, if they have virus circulating, that means that
active replication is taking place. The longer you wait, the lower the CD4, the more
damage to the immune system. And we know how hard immune reconstitution is.
Once you lost a memory cell, you will most likely never get it back.>>

Reading the guidelines it seemed to me that they were somewhat concerned that patients without symptoms or a significantly depressed immune system would not maintain the treatment regimen, thus encouraging resistance. So in a sense IMO they were more concerned with the spread of resistant virus than the optimal health of the patient at hand.
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